The Treatment of Bone Marrow Lesions Associated with Advanced Knee Osteoarthritis: Comparing Intraosseous and Intraarticular Injections with Bone Marrow Concentrate and Platelet Products

Background: Bone marrow lesions are a radiographic indication of bony pathology closely associated with advanced osteoarthritis the adjacent joint. Injection autologous orthobiologic products, including bone concentrate and platelet-rich plasma, have demonstrated safety efficacy in treating both (via intraarticular injection) intraosseous injection). The relative versus injection orthobiologics has not been evaluated at present time. Objectives: objective was to evaluate differences treatment, either as collateral result platelet products alone, or plus measured by patient reported outcomes. Study Design: This study employed prospective case-matched cohort design. Setting: took place single outpatient interventional orthopedic pain clinic. Methods: Using data from treatment registry knee patients, population patients who had undergone only injections platelets (for symptomatic osteoarthritis) were age, gender, disease severity series underwent injections. Self-reported outcomes for Numeric Pain Scale, International Knee Documentation Committee, lower extremity functional scale, modified assessment numeric evaluation compared between 2 groups. Results: Eighty included, 40 each group. Although outcome scores significantly improved groups, there no statistically significant based on type treatment. Limitations: There several limitations this study, multiple providers performing injections, varying onset symptoms additional after their initial that controlled. In addition, increasing sample size may be beneficial well, particularly large group, which did suggest possible improvement over intraarticular, although our sample. Limited availability well some missing other consider. Conclusion: Treating affect Key words: Intraosseous, concentrate, lesion, edema, osteoarthritis,